COMPARATIVE EVALUATION OF THE ANTIBACTERIAL EFFECTS OF Moringa oleifera AND Nigella sativa ON SOME CLINICAL BACTERIAL ISOLATES OBTAINED FROM IGBINEDION UNIVERSITY, OKADA, NIGERIA
Antibacterial susceptibility study of the aqueous, methanol and chloroform extract of Moringa oleifera and Nigella sativa was carried out to comparatively evaluate the antibacterial effects of these plants against some clinical isolates (Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa). The susceptibility of the bacterial isolates to the extract of M. oleifera and N. Sativa were determined by agar well diffusion and minimum inhibitory concentration (MIC) techniques. The findings from this study revealed that M. oleifera leaf extract exhibited better antibacterial effects than N. sativa seed extract, as indicated by their zones of inhibition and MIC values. The aqueous and chloroform extract of M. oleifera exhibited activity only against S. aureus and E. coli (MIC values of the aqueous and chloroform extract of M. oleifera against S. aureus and E. coli were reported as 3.91 mg/ml and 1.96 mg/ml for S. aureus, as well as 7.20 mg/ml and 31.25 mg/ml for E. coli), while the methanol extract of M. oleifera showed activity against all the three bacterial isolates (MIC values were 31.25 mg/ml, 3.91 mg/ml, and 125 mg/ml for S. aureus, E. coli and P. aeruginosa respectively). Unlike the chloroform extract of N. sativa which showed no activity against the three bacterial isolates, the aqueous and methanol extract of N. sativa seeds showed some activity only against S. aureus with a MIC value of 31.25 mg/ml each. Evidence of the antibacterial effect of M. oleifera and N. sativa, as revealed in this study, underscores their therapeutic utilization in traditional medicine.