Effect of Some Medicinal Plants: Urticadioica, Viscum album, Eucalyptus globulus and Olea Europeaonalloxan-İnduced Diabetic Mice

Özet

Current antidiabetic treatmentsare based on synthetic agents which existingseveral adverse effects in long term uses. Therefore, it is needed to develop new and safer pharmaceuticals as alternative for treatment of diabetes. Traditionally usedplants are important source of potential antidiabetic agents. In this study four plants used traditionallyfor treatment of many disease were evaluated for their antidiabetic action.This study was focused onthe effects of Urticadioica(UD),Viscum album(VA), Eucalyptus globulus(EG) andOleaeuropea(OE)extracts on blood and organ glucose concentrations of hyperglycemic mice. Hyperglycemia was induced by alloxan and the antidiabetic drug glutril used for the comparison. Aqueous extracts of UD, VA,EG and OE andglutril were given three drops orally every day and blood glucose levels were measured in two days interval at eight periods.It was found that blood glucose concentrations of UD, VA, EG, OE and glutril groups were 90.9  3.9 mg/dl, 95.22.4 mg/dl, 75.3±3.1 mg/dl, 93.7±2.7 mg/dl and 96.32.3 mg/dl, respectively (P<0.001). The all tested plants were decreased fasting blood glucose levels similar to antidiabetic agent glutril. Additionally, no adverse effects were determined in plant extracts treated groups. Further investigation is needed to determine constituents which is responsible from activity andthese plants can be use as alternative therapeutics.