INVESTIGATION OF ANTI-CANCER AND ANTIOXIDANT PROPERTIES OF ZINGERONE

Özet

Zingeron (4-(4-hydroxy-3-methoxyphenyl)-2-butanone) is one of the non-volatile, pungent, phenolic compounds of ginger and this compound is known to have anti-cancer effects. However, comparison of the effect of zingerone on a breast cancer cell line, MCF-7, with that of a healthy cell line, HUVEC (Human Umbilical Vein Endothelial Cells), has been quite limited. In this study; zingerone cytotoxicity on the cells was determined by the MTS test. Accordingly, IC₅₀ values for MCF-7 and HUVEC cells were calculated as 2.8 mM and 9.5 mM, respectively. When the values in the two cell groups were compared with the Two-way ANOVA test, it was understood that the p value was less than 0.001. Thus, we concluded that zingerone cytotoxicity on these cells was significantly distinct. The study also examined the DPPH free radical scavenging effect of zingerone and approved that zingerone has antioxidant properties.