Centaurea cataonica BOISS.ET HAUSSKN. ENDEMİK BİTKİSİNİN BİYOLOJİK AKTİVİTELERİ VE SİTOTOKSİK AKTİVİTESİNİN İNCELENMESİ

Abstract

In this study,the biological activities and cytotoxic effects of the endemic plant Centaurea cataonica. were investigated under in-vitro conditions. In the antimicrobial activity test, a totally of 6 bacterial samples were studied and the disc diffusion method was used. As a result of the antimicrobial test, it was observed that the plant material formed a zone diameter on all microorganisms. Moreover the antioxidant capacity test was performed using the 2,2-Diphenyl-1-picrylhydralysis (DPPH) radical quenching capacity. The results showed that the antioxidant capacity of the plant material increases from low to high concentrations. The cytotoxic acitivty was determined with two cell lines, human breast cancer cell line (MCF-7) and human umbilical vein endothelial cells (HUVEC) and MTS (Tetrazolium salt) viabilty test. It has been observed that plant material at high concentrations has a cytotoxic effect on cancerous cell lines.